The 2021 NFL season will be a third way through after week 6. Fortunately, as the bye weeks begin, we still have some superb betting options that hopefully make all of us some money:
- A highly anticipated contest between the undefeated Arizona Cardinals and the always dangerous Cleveland Browns.
- The Seattle Seahawks minus QB Russell Wilson travel to face the improved Pittsburgh Steelers.
- The MNF matchup in week 6 between the high octane Buffalo Bills offense traveling to face the Tennessee Titans and MVP candidate Derrick Henry.
Now, let’s take a look at our top 3 betting Predictions for week 6 of the 2021 NFL season.
Arizona Cardinals at Cleveland Browns (-2.5, 51.5 o/u)
Sunday 4:05 p.m. ET, CBS
Former No.1 overall picks out of Oklahoma Baker Mayfield and Kyler Murray face off on Sunday for the first time in their careers. Mayfield only has 4 passing TDs this season, well behind league leader Tom Bardy with 17. Cleveland will have the services of WR Jarvis Landry, who returns from IR.
Kyler Murray is a top MVP candidate leading Arizona to a 5-0 record to start the season. There is some concern about Murray and his injured shoulder but he was a full participant in Friday’s practice, which is good news for Cards fans. Even so, the banged-up Cleveland defense will need to play exceptional to contain the Cardinals’ wideouts DeAndre Hopkins, Christian Kirk, A.J. Green, and Rondale Moore. Arizona is playing as good as anyone in the league, plus the injuries to Cleveland RB Nick Chubb (calf), who won’t play Sunday, is too inviting to ignore. I’ll gladly go with Arizona as a small road dog.
Pick: Arizona Cardinals Money Line +150
Seattle Seahawks at Pittsburgh Steelers (-5, 42.5 o/u)
Sunday 8:20 p.m. ET, NBC
The Seahawks travel to a Hines Field in Pittsburgh with Geno Smith as their starting quarterback due to a finger injury to Russell Wilson. The Steelers rookie RB Najee Harris secured his first 100+ yard rushing game last week and looks to take advantage of Seattles’ rushing defense that currently ranks 3rd worst in the league.
Steelers QB Ben Roethlisberger is coming off a 253-yard, two-touchdown outing in Pittsburgh’s Week 5 win over Denver. Pittsburgh will be without WR JuJu Smith-Schuster, who suffered a season-ending shoulder injury last week. However, Pittsburgh is still at home against a backup QB. There is no way I ignore this betting gift. Take Pittsburgh and the points.
Pick: Pittsburgh Steelers – 5
Buffalo Bills (-5.5, 53.5 o/u) at Tennessee Titans
Monday 8:15 p.m. ET, ESPN
The Bills had an emotional win last week in Kansas City and will take their league-leading 34.4 points per game into Tennessee against a Titans’ team that is averaging a respectful 26.4 points per game. In the last four weeks, the Buffalo Bills have outscored their opponents 156-41. Impressive. Besides having the best offense in the league, Buffalo also sports the 2nd ranked passing defense and 3rd ranked defense against the run. If Buffalo can keep Derrick Henry in check, they should secure another W in week 6 .
Pick: Buffalo Bills -5.5
We will gladly put our money on these NFL Predictions for Week 6 of the 2021 season. Good Luck and enjoy the games!
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